In the effort towards a QRA on skin sensitization based on new approach methodologies (NAMs) instead of the LLNA, IDEA provides a multi-stakeholder forum to facilitate the generation of a guidance framework based on NAMs to identify a NESIL for fragrance ingredients (FIs).
Six years in IDEA – what is our progress in understanding and managing the pre-hapten question?
The European Parliament in Brussels hosts the fifth Annual Review of the IDEA Project on 25 February 2019.
IDEA experts reunited on 12 December 2018 in Brussels to continue the discussion on Characterization and Categorization (C&C) of fragrance allergens.
The International Dialogue for the Evaluation of Allergens (IDEA) held a Workshop on 16-17 May looking at the replacement of animal testing in quantitative risk assessment (QRA) for skin sensitisation.
Under the framework of IDEA, a revised methodlogy on Quantitative Risk Assessment (QRA2) has been developped. This revised methodlogy focuses on total exposure of consumers to individual fragrances.
The IDEA Management Team met representatives of the European Commission’s Joint Research Centre (JRC) on 28 June in Ispra, Italy.
Every year, since this is a long-term project, an Annual Review takes place to monitor and validate progress and update the program and priorities when needed and to ensure that all scientific stakeholders can express their views and get further clarification on the project.
Over 2015, IDEA worked on the development of a revised QRA methodology (QRA2), focusing on total exposure of consumers to individual fragrances. For this purpose, a joint academia/industry IDEA working group has reviewed the uncertainties where a safety assessment factor (SAF) is warranted and the scientific basis for the assignment of each SAF value. Moreover, an aggregate exposure model based on actual consumer use of products which involves the utilization of these SAF values has been developed.
The 4th IDEA Workshop on Pre- and Pro- haptens took place in Brussels.