The objectives of this Workshop were:
- To further drive mechanistic understanding of pre- and prohapten formation and to bridge findings with clinical data.
- Obtain an agreement on what is known respectively unknown and lay out pathways to close these knowledge gaps.
- Work towards solid documentation of current knowledge and its implementation for risk management purposes.
The IDEA Hydroperoxides TF provided an update on the method development and discussed with the participants the remaining activities and next steps. Clinical and experimental data, including cross-reactivity and metabolism processes, was reviewed to get a deeper understanding on the role of prehaptens in contact allergy. Regarding prohaptens, the discussion was focused on the latest scientific and on the methodological challenges to apprehend their formation.
As concluded during the workshop and as reflected in the initial summary for the Rapporteur (Prof. James Bridges), the next steps will be focused on:
- The progress of the ongoing research work to deeply understand the role and formation of pre- and prohaptens in the development of contact allergy dermatitis
- The inclusion of pre- and prohaptens in the current risk assessment of fragrance sensitizers.