IDEA organized a second workshop focusing on the capacity of NAMs to derive skin sensitization potency with the aim to derive a starting point (NESIL) for use in Quantitative Risk Assessment of fragrance ingredients.
IDEA organized a second workshop focusing on the capacity of NAMs to derive skin sensitization potency with the aim to derive a starting point (NESIL) for use in Quantitative Risk Assessment of fragrance ingredients.
IDEA organized a second workshop focusing on the capacity of NAMs to derive skin sensitization potency with the aim to derive a starting point (NESIL) for use in Quantitative Risk Assessment of fragrance ingredients. The event brought together representatives from the fragrance and cosmetics industry, academia, and regulators, with the International Fragrance Association (IFRA) playing an active role in supporting the dialogue.
A central theme of this workshop was the extended Reference Chemicals Potency List (RCPL), developed within the IDEA NAM (New Approach Methodologies) workstream. The RCPL has grown significantly - from its initial 33 substances to a current set of 110 chemicals, primarily comprising fragrance materials. Participants in the workshop agreed that the RCPL offers a robust foundation for evaluating how individual or combined non-animal methods can accurately measure sensitizing potency. This progress lays the groundwork for more effective risk assessments conducted without animal testing.
The second part of the workshop examined the application of the RCPL to three selected NAMs, with a focus on addressing uncertainty in predictions. Experts concluded there is strong evidence that NAMs can reliably predict skin sensitizer potency for fragrance ingredients.
All documents from the meeting are available below:
