IDEA - International Dialogue for the Evaluation of Allergens

IDEA Pre- and pro- haptens Workshop

16 - 17 October 2019

Six years in IDEA – what is our progress in understanding and managing the pre-hapten question?

> Download workshop agenda

Spontaneous oxidation of terpenes in presence of air to form sensitising hydroperoxides was a potential risk highlighted by the SCCS opinion and investigated within IDEA. Over these six years many additional studies were published by dermatologists on patch test data and potential elicitation by hydroperoxides.

In parallel IDEA developed, validated and applied analytical methods for hydroperoxide detection in products. These two parallel information streams do not yet match up and it is unclear how the clinical picture can be related to the analytical data.

The workshop brings together experts helping to interpret the data and define potential next steps to resolve this conundrum. Experts were invited to provide their view of the issue and include in their presentation a discussion of questions listed below, as far as they have a view on them.

> Download the discussion topics
> Download the conclusions

Download the presentations:
> Ahmed Rahzi: Highly selective and sensitive 2D-LC/MS/MS for fragrance HP analysis
> Carsten Goebel: A risk assessor's perspective on pre- and pro-haptens
> Franz Oesch: Xenobiotic metabolising capabilities of cell preparations used in KE1, KE2 and KE3 tests
> Helmut Greim: Reactive Metabolites: Their Nature and Toxicity
> Jean-Pierre Lepoittevin: Some views on the prehapten paradigm...
> Jean-Pierre Lepoittevin: Skin xenobiotic metabolism and review of structural consideration
> Steve Enoch: The Effectiveness of In Silico Methods in Predicting the Formation of Active Metabolites